Clec14a Gene Summary [Mouse]
Predicted to enable extracellular matrix binding activity and extracellular matrix protein binding activity. Involved in cell migration involved in sprouting angiogenesis. Acts upstream of or within with a positive effect on vascular endothelial growth factor receptor-3 signaling pathway. Acts upstream of or within with a negative effect on vascular endothelial growth factor receptor-2 signaling pathway. Acts upstream of or within lymphangiogenesis and sprouting angiogenesis. Located in collagen-containing extracellular matrix. Is expressed in bladder; central nervous system; embryo mesenchyme; and head blood vessel. Orthologous to human CLEC14A (C-type lectin domain containing 14A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clec14a |
| Official Name | C-type lectin domain family 14, member a [Source:MGI Symbol;Acc:MGI:1914114] |
| Ensembl ID | ENSMUSG00000045930 |
| Bio databases IDs | |
| Aliases | C-type lectin domain family 14, member a |
| Synonyms | 1200003C23Rik, C14orf27, CEG1, C-type lectin domain containing 14A, C-type lectin domain family 14, member a, EGFR-5, RGD1306232 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clec14a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- protein binding
- Coagulation Factor Xa inhibitory site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- preeclampsia
- focal segmental glomerulosclerosis
- minimal change nephrotic syndrome
- membranous glomerulonephritis
role in cell
- expression in
- apoptosis
- infiltration by
- production in
- injury
- disarrangement in
- disarrangement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clec14a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lymphangiogenesis
- cell migration involved in sprouting angiogenesis
- cell migration
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- protein binding
- carbohydrate binding