Nudt6 Gene Summary [Mouse]
Predicted to enable ADP-ribose diphosphatase activity; NAD binding activity; and NADH pyrophosphatase activity. Predicted to be involved in negative regulation of cell cycle and negative regulation of cell population proliferation. Predicted to be located in cytoplasm. Is expressed in brain. Orthologous to human NUDT6 (nudix hydrolase 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nudt6 |
| Official Name | nudix (nucleoside diphosphate linked moiety X)-type motif 6 [Source:MGI Symbol;Acc:MGI:2387618] |
| Ensembl ID | ENSMUSG00000050174 |
| Bio databases IDs | |
| Aliases | nudix (nucleoside diphosphate linked moiety X)-type motif 6 |
| Synonyms | ASFGF2, Asfgf2b, FGF2AS, FGF-AS, Gfg, GFG-1, MGC27904, nudix hydrolase 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nudt6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NUDIX domain
- Nudix hydrolase domain
- nucleotide diphosphatase
- enzyme
- NUDIX hydrolase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
regulates
- FGF2
- MAPK
role in cell
- expression in
- proliferation
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nudt6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- negative regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- NADH pyrophosphatase activity
- ADP-ribose diphosphatase activity
- NAD binding