Mtif2 Gene Summary [Mouse]
Predicted to enable ribosomal small subunit binding activity; translation factor activity, RNA binding; and translation initiation factor activity. Predicted to be involved in mitochondrial translational initiation and ribosome disassembly. Located in mitochondrion. Is expressed in liver lobe; testis; and vibrissa. Orthologous to human MTIF2 (mitochondrial translational initiation factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Mtif2 |
| Official Name | mitochondrial translational initiation factor 2 [Source:MGI Symbol;Acc:MGI:1924034] |
| Ensembl ID | ENSMUSG00000020459 |
| Bio databases IDs | |
| Aliases | mitochondrial translational initiation factor 2 |
| Synonyms | 2310038D14RIK, 2410112O06Rik, IF-2MT, IF-2(Mt), mitochondrial initiation factor 2, mitochondrial translational initiation factor 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mtif2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- translation initiation factor IF-2
- nucleic acid binding translation factor
- Ras family
- 50S ribosome-binding GTPase
- translation initiation factor aIF-2/yIF-2
- translation regulator
- GTP binding
- Domain II of Elongation factor Tu (EF-Tu)-like proteins
- PRK04004
- small GTP-binding protein domain
- translation initiation factor
- Elongation factor Tu GTP binding domain
- Ras of Complex, Roc, domain of DAPkinase
- Translation-initiation factor 2
- P-loop containing Nucleoside Triphosphate Hydrolases
- ribosomal small subunit binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mtif2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosome disassembly
- mitochondrial translational initiation
- regulation of translational initiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- translation initiation factor activity
- RNA binding
- GTPase activity
- ribosomal small subunit binding
- translation factor activity, nucleic acid binding