Skp2 Gene Summary [Mouse]
Enables ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of double-strand break repair via homologous recombination and protein K63-linked ubiquitination. Acts upstream of or within several processes, including mitotic cell cycle phase transition; positive regulation of intracellular estrogen receptor signaling pathway; and positive regulation of protein polyubiquitination. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including blastocyst; brain; compacted morula; and retina nuclear layer. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Skp2 |
| Official Name | S-phase kinase-associated protein 2 [Source:MGI Symbol;Acc:MGI:1351663] |
| Ensembl ID | ENSMUSG00000054115 |
| Bio databases IDs | |
| Aliases | S-phase kinase-associated protein 2 |
| Synonyms | 4930500A04Rik, AC139209.1, cyclin A-associated kinase, FBL1, F-box protein Skp2, FBXL1, FLB1, FWD1, p45, p45Skp2, RGD1562456, S-PHASE KINASE-ASSOCIATED protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Skp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- leucine rich domain
- leucine-rich repeat
- F-box domain superfamily
- F-box-like
- nuclear localization sequence
- protein binding activity, bridging
- protein binding
- identical protein binding
- substrate binding domain
Pathways
Biological processes and signaling networks where the Skp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- neoplasia
- castration refractory prostate cancer
- tubulo-interstitial fibrosis
- impaired glucose tolerance
- rheumatoid arthritis
- obesity
- cancer
- severe acute respiratory syndrome
- schizophrenia
role in cell
- phosphorylation in
- proliferation
- growth
- quantity
- number
- expression in
- activation in
- G2/M phase
- apoptosis
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- basal compartment
- cytosol
- nucleoplasm
- perinuclear space
- nucleoli
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Skp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- G2/M transition of mitotic cell cycle
- innate immune response
- G1/S transition of mitotic cell cycle
- positive regulation of intracellular estrogen receptor signaling pathway
- defense response to virus
- protein K63-linked ubiquitination
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- regulation of apoptotic process
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- SCF ubiquitin ligase complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding