Nrgn Gene Summary [Mouse]
Enables calmodulin binding activity. Predicted to be involved in positive regulation of long-term synaptic potentiation and postsynaptic modulation of chemical synaptic transmission. Predicted to act upstream of or within intracellular signal transduction. Predicted to be located in several cellular components, including dendritic spine head; neuronal cell body; and trans-Golgi network transport vesicle membrane. Predicted to be active in glutamatergic synapse and postsynaptic membrane. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and stomach. Orthologous to human NRGN (neurogranin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nrgn |
| Official Name | neurogranin [Source:MGI Symbol;Acc:MGI:1927184] |
| Ensembl ID | ENSMUSG00000053310 |
| Bio databases IDs | |
| Aliases | neurogranin |
| Synonyms | 0710001B06Rik, AI838505, BICKS, hng, Neurogranin, NG, NG/RC3, Pss1, RC3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrgn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- binding protein
- calmodulin binding
- phosphatidylinositol-3,4,5-triphosphate binding
- IQ domain
- calmodulin binding domain
Pathways
Biological processes and signaling networks where the Nrgn gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- Huntington disease
- schizophrenia
- pervasive developmental disorder
- lung adenocarcinoma
- lung adenocarcinoma formation
- major depression
- Alzheimer disease
- pemphigus vulgaris
- bipolar disorder
role in cell
- apoptosis
- synaptic transmission
- signal transduction in
- excitability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- cytosol
- postsynaptic membrane
- trans Golgi network
- mitochondrial membrane
- dendritic spine head
- neurites
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrgn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- nervous system development
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- calmodulin binding