Bola3 Gene Summary [Mouse]
Acts upstream of or within several processes, including energy homeostasis; protein lipoylation; and response to lipoic acid. Is active in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 2. Orthologous to human BOLA3 (bolA family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bola3 |
| Official Name | bolA-like 3 (E. coli) [Source:MGI Symbol;Acc:MGI:1925903] |
| Ensembl ID | ENSMUSG00000045160 |
| Bio databases IDs | |
| Aliases | bolA-like 3 (E. coli) |
| Synonyms | 1810056O20Rik, bolA family member 3, MMDS2, RGD1305975 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bola3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BolA-like protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bola3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- cell redox homeostasis
- iron-sulfur cluster assembly
Cellular Component
Where in the cell the gene product is active
- nuclear body
- mitochondrial matrix
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding