Ubr2 Gene Summary [Mouse]
Enables histone H2A ubiquitin ligase activity. Involved in several processes, including meiotic nuclear division; negative regulation of gene expression, epigenetic; and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Acts upstream of or within male meiosis I and ubiquitin-dependent protein catabolic process. Located in chromatin. Part of ubiquitin ligase complex. Is expressed in several structures, including alimentary system; endocrine gland; eye; genitourinary system; and trachea. Orthologous to human UBR2 (ubiquitin protein ligase E3 component n-recognin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ubr2 |
| Official Name | ubiquitin protein ligase E3 component n-recognin 2 [Source:MGI Symbol;Acc:MGI:1861099] |
| Ensembl ID | ENSMUSG00000023977 |
| Bio databases IDs | |
| Aliases | ubiquitin protein ligase E3 component n-recognin 2 |
| Synonyms | 9930021A08Rik, bA49A4.1, C6ORF133, dJ242G1.1, dJ392M17.3, E130209G04Rik, E3alpha-II, KIAA0349, mKIAA0349, ubiquitin protein ligase E3 component n-recognin 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ubr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative zinc finger in N-recognin (UBR box)
- Putative zinc finger in N-recognin
- binding protein
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- UBR-box
- enzyme
- protein binding
- Proteolysis_6 C-terminal
- ATP-dependent Clp protease adaptor protein ClpS
- amino acid binding
Pathways
Biological processes and signaling networks where the Ubr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- lung carcinoma
- lung carcinoma process
- growth failure
- familial multiple sclerosis
- oligozoospermia
- pericardial effusion
- congenital posterior urethral valve disorder
role in cell
- expression in
- differentiation
- apoptosis
- activation in
- degradation in
- formation
- response by
- ubiquitination in
- meiosis I
- meiosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- chromosomal arms
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ubr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- reciprocal meiotic recombination
- male meiosis
- spermatogenesis
- male meiosis I
- positive regulation of T cell receptor signaling pathway
- proteasomal ubiquitin-dependent protein catabolic process
- cellular response to leucine
- ubiquitin-dependent protein catabolic process via the N-end rule pathway
- negative regulation of transposition, RNA-mediated
- heterochromatin assembly
- protein K63-linked ubiquitination
- negative regulation of TOR signaling cascade
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytoplasm
- cytosol
- chromatin
Molecular Function
What the gene product does at the molecular level
- leucine binding
- zinc ion binding
- protein binding