PGLYRP1 Gene Summary [Human]
Enables peptidoglycan binding activity and peptidoglycan immune receptor activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide; killing of cells of other organism; and response to bacterium. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PGLYRP1 |
| Official Name | peptidoglycan recognition protein 1 [Source:HGNC Symbol;Acc:HGNC:8904] |
| Ensembl ID | ENSG00000008438 |
| Bio databases IDs | |
| Aliases | peptidoglycan recognition protein 1 |
| Synonyms | Peptidoglycan Recognition, peptidoglycan recognition protein 1, PGLYRP, PGRP, PGRP-S, SBBI68, TAG7, Tasg7, TNFSF3L, TREM-1 ligand |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PGLYRP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-acetylmuramoyl-L-alanine amidase
- Hsp70 protein binding
- peptidoglycan binding
- receptor agonist activity
- peptidoglycan recognition
- transmembrane receptor
- PGRP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- septic shock
- rheumatoid arthritis
- sepsis
- Staphylococcus aureus pneumonia
- severe acute respiratory syndrome
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
regulates
- cytokine
- IFNG
role in cell
- apoptosis
- necroptosis
- cell death
- cellular infiltration by
- number
- cytostasis
- cell viability
- phagocytosis by
- detection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- secretory granule lumen
- cell surface
- Extracellular Space
- organelle lumens
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PGLYRP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- innate immune response
- negative regulation of natural killer cell differentiation involved in immune response
- peptidoglycan catabolic process
- negative regulation of inflammatory response
- killing of cells of other organism
- detection of bacterium
- interaction with host
- negative regulation of interferon-gamma production
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- phagocytic vesicle lumen
- specific granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- peptidoglycan binding
- peptidoglycan receptor activity
- zinc ion binding
- receptor agonist activity
- N-acetylmuramoyl-L-alanine amidase activity
- Hsp70 protein binding
- binding, bridging