YWHAZ Gene Summary [Human]
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
Details
| Type | Protein Coding |
| Official Symbol | YWHAZ |
| Official Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [Source:HGNC Symbol;Acc:HGNC:12855] |
| Ensembl ID | ENSG00000164924 |
| Bio databases IDs | |
| Aliases | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta, 14-3-3 zeta, 14-3-3 delta |
| Synonyms | 1110013I11RIK, 14-3-3 delta, 14-3-3z, 14-3-3-zeta, 14-3-3 ZETA/delta, 14-3-3 δ, 14-3-3-ζ, 14-3-3 ζ/δ, HEL4, HEL-S-3, HEL-S-93, KCIP-1, POPCHAS, Protein kinase c inhibitor 1 beta/alpha, Protein kinase c inhibitor 1 β/α, Protein kinase C inhibitor protein 1 zeta/delta, Protein kinase C inhibitor protein 1 ζ/δ, Tyr mono, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein ζ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, ζ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, ζ polypeptide, Tyrosine 3-Monooxygenase ζ Polypeptide, YMHAZ, YWHAD |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human YWHAZ often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- protein kinase binding
- 14-3-3 domain
- protein phosphatase binding
- transcription factor binding
- protein domain specific binding
- enzyme
- protein binding
- identical protein binding
- phosphoprotein amino acid binding
- phosphorylation site
- binding protein
- ion channel binding
- 14-3-3 protein
Pathways
Biological processes and signaling networks where the YWHAZ gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- neoplasia
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- Huntington disease
- organismal death
- Alzheimer disease
- glioma formation
- diffuse large B-cell lymphoma
- plasma cell myeloma
role in cell
- expression in
- activation in
- apoptosis
- formation in
- proliferation
- cellular infiltration by
- cell death
- binding in
- growth
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- glutaminergic synapse
- organelle
- cell periphery
- perinuclear region
- cellular membrane
- actin cytoskeleton
- membrane skeleton
- Nucleus
- Golgi Apparatus
- Mitochondria
- lipid droplets
- cytosol
- lateral plasma membrane
- nucleoplasm
- synaptic vesicles
- growth cone
- synaptosomes
- synapse
- actin foci
- cell membrane leading edge
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human YWHAZ gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synapse maturation
- negative regulation of protein localization to nucleus
- Golgi reassembly
- signal transduction
- protein localization
- protein phosphorylation
- negative regulation of innate immune response
- cellular response to glucose starvation
- synaptic target recognition
- negative regulation of transcription from RNA polymerase II promoter
- respiratory system process
- ERK1 and ERK2 cascade
- protein targeting
- regulation of ERK1 and ERK2 cascade
- regulation of protein stability
- establishment of Golgi localization
- angiogenesis
- negative regulation of apoptotic process
- tube formation
- lung development
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- focal adhesion
- melanosome
- cytoplasm
- blood microparticle
- cytosol
- vesicle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein domain specific binding
- ubiquitin protein ligase binding
- RNA binding
- protein binding
- cadherin binding
- phosphoserine binding
- ion channel binding