INSRR Gene Summary [Human]
Enables transmembrane receptor protein tyrosine kinase activity. Involved in actin cytoskeleton reorganization; cellular response to alkaline pH; and protein autophosphorylation. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | INSRR |
| Official Name | insulin receptor related receptor [Source:HGNC Symbol;Acc:HGNC:6093] |
| Ensembl ID | ENSG00000027644 |
| Bio databases IDs | |
| Aliases | insulin receptor related receptor |
| Synonyms | Insulin receptor-related receptor, IRR, Sirr |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human INSRR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein kinase (unclassified specificity)
- Furin-like cysteine rich region
- Protein tyrosine and serine/threonine kinase
- protein binding
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Receptor L domain
- FU
- Protein Kinases, catalytic domain
- cytoplasmic domain
- transmembrane receptor protein tyrosine kinase
- FN3
- Furin-like repeat, cysteine-rich
- intracellular domain
- Furin-like repeats
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- hyperglycemia
- primary sex reversal
- endometriosis
- ketoaciduria
- neuroblastoma
- neuroblastoma formation
- MYCN amplification negative neuroblastoma
regulated by
- 8-bromo-cAMP
- medroxyprogesterone acetate
- beta-estradiol
- PMSG
- Exendin4
- IL1B
- valproic acid
- oleoyl-estrone
- NFkB (complex)
- selumetinib
regulates
- AKT
- D-glucose
- glycogen synthase
- Ins1
- bicarbonate
- LATS
role in cell
- cell viability
- response by
- lipolysis in
- organization
- mass
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human INSRR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male sex determination
- multicellular organismal development
- insulin receptor signaling pathway
- protein autophosphorylation
- cellular response to alkalinity
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of kinase activity
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- insulin receptor complex
- receptor complex
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol 3-kinase binding
- ATP binding
- protein binding
- insulin-activated receptor activity
- transmembrane receptor protein tyrosine kinase activity
- insulin receptor substrate binding