SRPRB Gene Summary [Human]
The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SRPRB |
| Official Name | SRP receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:24085] |
| Ensembl ID | ENSG00000144867 |
| Bio databases IDs | |
| Aliases | SRP receptor subunit beta |
| Synonyms | Ab2-417, APMCF1, Ba1-667, Cc1-8, LOC100503658, Signal recognition particle receptor, B subunit, SR-beta, SRP receptor subunit beta, SRP receptor subunit β, SR-β |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SRPRB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sar1p-like members of the Ras-family of small GTPases
- ubiquitin protein ligase binding
- Ferrous iron transport protein B
- ADP-ribosylation factor family
- Signal recognition particle receptor beta subunit
- transmembrane domain
- 50S ribosome-binding GTPase
- Ras of Complex, Roc, domain of DAPkinase
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum mitochondria contact site
- cellular membrane
- endoplasmic reticulum membrane
- cytoplasmic microtubule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SRPRB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
- protein targeting to ER
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- membrane
- cytoplasmic microtubule
- signal recognition particle receptor complex
Molecular Function
What the gene product does at the molecular level
- GTP binding