MAT2B Gene Summary [Human]
The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Details
| Type | Protein Coding |
| Official Symbol | MAT2B |
| Official Name | methionine adenosyltransferase 2B [Source:HGNC Symbol;Acc:HGNC:6905] |
| Ensembl ID | ENSG00000038274 |
| Bio databases IDs | |
| Aliases | methionine adenosyltransferase 2B, short chain dehydrogenase/reductase family 23E, member 1 |
| Synonyms | 1110064C04RIK, 2410018D16RIK, Locuslink 108645, MAT-II, MATIIbeta, methionine adenosyltransferase 2 non-catalytic beta subunit, methionine adenosyltransferase 2 non-catalytic beta subunit methionine, methionine adenosyltransferase 2 non-catalytic β subunit, methionine adenosyltransferase 2 non-catalytic β subunit methionine, Nbla02999, SDR23E1, TGR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAT2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- Male sterility protein
- TIGR01777 family protein
- NAD dependent epimerase/dehydratase family
- enzyme binding
- enzyme
- protein binding
- dTDP-4-dehydrorhamnose reductase
- methionine adenosyltransferase
- RmlD substrate binding domain
- methionine adenosyltransferase regulator
Pathways
Biological processes and signaling networks where the MAT2B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- epithelial cancer
- liver cancer
regulated by
- sodium arsenite
- RYR1
- Hbx
role in cell
- binding in
- growth
- expression in
- apoptosis
- phosphorylation in
- proliferation
- migration
- cell cycle progression
- repression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAT2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- S-adenosylmethionine biosynthetic process
- one-carbon metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- methionine adenosyltransferase complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- methionine adenosyltransferase regulator activity
- enzyme binding