Mat2b Gene Summary [Rat]
Predicted to enable enzyme binding activity and methionine adenosyltransferase regulator activity. Predicted to be involved in S-adenosylmethionine biosynthetic process. Predicted to be located in nucleus. Predicted to be part of methionine adenosyltransferase complex. Orthologous to human MAT2B (methionine adenosyltransferase 2 non-catalytic beta subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mat2b |
| Official Name | methionine adenosyltransferase 2B [Source:RGD Symbol;Acc:1593534] |
| Ensembl ID | ENSRNOG00000003177 |
| Bio databases IDs | |
| Aliases | methionine adenosyltransferase 2B |
| Synonyms | 1110064C04RIK, 2410018D16RIK, Locuslink 108645, MAT-II, MATIIbeta, methionine adenosyltransferase 2 non-catalytic beta subunit, methionine adenosyltransferase 2 non-catalytic beta subunit methionine, methionine adenosyltransferase 2 non-catalytic β subunit, methionine adenosyltransferase 2 non-catalytic β subunit methionine, Nbla02999, SDR23E1, TGR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mat2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- Male sterility protein
- TIGR01777 family protein
- NAD dependent epimerase/dehydratase family
- enzyme binding
- enzyme
- protein binding
- dTDP-4-dehydrorhamnose reductase
- methionine adenosyltransferase
- RmlD substrate binding domain
- methionine adenosyltransferase regulator
Pathways
Biological processes and signaling networks where the Mat2b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- epithelial cancer
- liver cancer
regulated by
- sodium arsenite
- RYR1
- Hbx
role in cell
- binding in
- growth
- expression in
- apoptosis
- phosphorylation in
- proliferation
- migration
- cell cycle progression
- repression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mat2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- S-adenosylmethionine biosynthetic process
- one-carbon metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- methionine adenosyltransferase complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- methionine adenosyltransferase regulator activity
- enzyme binding