GUCA2B Gene Summary [Human]
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | GUCA2B |
| Official Name | guanylate cyclase activator 2B [Source:HGNC Symbol;Acc:HGNC:4683] |
| Ensembl ID | ENSG00000044012 |
| Bio databases IDs | |
| Aliases | guanylate cyclase activator 2B, prepro-uroguanylin |
| Synonyms | GCAP2, GCAP-II, guanylate cyclase activator 2B, pre-pro-uroguanylin, UGN, Uroguanylin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GUCA2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Guanylin precursor
Pathways
Biological processes and signaling networks where the GUCA2B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- colorectal cancer
- salt-insensitive hypertension
- ulcerative colitis
- aldosterone producing adrenocortical adenoma
- colorectal adenoma
- colorectal adenoma formation
role in cell
- expression in
- apoptosis
- proliferation
- firing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- photoreceptor outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GUCA2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cGMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanylate cyclase activator activity