Guca2b Gene Summary [Rat]
Predicted to enable guanylate cyclase activator activity. Involved in cGMP-mediated signaling. Predicted to be located in extracellular region. Orthologous to human GUCA2B (guanylate cyclase activator 2B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Guca2b |
| Official Name | guanylate cyclase activator 2B [Source:RGD Symbol;Acc:620044] |
| Ensembl ID | ENSRNOG00000008979 |
| Bio databases IDs | |
| Aliases | guanylate cyclase activator 2B |
| Synonyms | GCAP2, GCAP-II, guanylate cyclase activator 2B, pre-pro-uroguanylin, UGN, Uroguanylin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Guca2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Guanylin precursor
Pathways
Biological processes and signaling networks where the Guca2b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- colorectal cancer
- salt-insensitive hypertension
- ulcerative colitis
- aldosterone producing adrenocortical adenoma
- colorectal adenoma
- colorectal adenoma formation
role in cell
- expression in
- apoptosis
- proliferation
- firing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- photoreceptor outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Guca2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cGMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanylate cyclase activator activity