GRIPAP1 Gene Summary [Human]
This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. [provided by RefSeq, Aug 2013]
Details
| Type | Retained Intron |
| Official Symbol | GRIPAP1 |
| Official Name | GRIP1 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18706] |
| Ensembl ID | ENSG00000068400 |
| Bio databases IDs | |
| Aliases | GRIP1 associated protein 1 |
| Synonyms | A130070G01Rik, DKFZp434P0630, DXImx47e, GRASP-1, GRIP1 associated protein 1, mKIAA1167, Sfc10 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRIPAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Crescentin protein
- guanyl-nucleotide exchange factor
- protein binding
- ionotropic glutamate receptor binding
- identical protein binding
- HOOK protein coiled-coil region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytosolic synaptosomal fraction
- membrane fraction
- glutaminergic synapse
- intracellular membrane-bounded organelle
- cellular membrane
- endosomes
- cytosol
- presynaptic membrane
- nucleoplasm
- synaptosomes
- synapse
- recycling endosomes
- perikaryon
- dendrites
- postsynaptic density
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRIPAP1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- dendrite
- intracellular membrane-bounded organelle
- blood microparticle
- cytosol
- recycling endosome membrane
- neuronal cell body
- axon
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ionotropic glutamate receptor binding
- identical protein binding
- protein binding
- guanyl-nucleotide exchange factor activity