Gripap1 Gene Summary [Rat]
Enables guanyl-nucleotide exchange factor activity and ionotropic glutamate receptor binding activity. Involved in negative regulation of receptor clustering; regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane; and regulation of recycling endosome localization within postsynapse. Located in dendrite; neuronal cell body; and presynaptic membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic early endosome membrane. Orthologous to human GRIPAP1 (GRIP1 associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gripap1 |
| Official Name | GRIP1 associated protein 1 [Source:RGD Symbol;Acc:621249] |
| Ensembl ID | ENSRNOG00000009071 |
| Bio databases IDs | |
| Aliases | GRIP1 associated protein 1 |
| Synonyms | A130070G01Rik, DKFZp434P0630, DXImx47e, GRASP-1, GRIP1 associated protein 1, mKIAA1167, Sfc10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gripap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Crescentin protein
- guanyl-nucleotide exchange factor
- protein binding
- ionotropic glutamate receptor binding
- identical protein binding
- HOOK protein coiled-coil region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytosolic synaptosomal fraction
- membrane fraction
- glutaminergic synapse
- intracellular membrane-bounded organelle
- cellular membrane
- endosomes
- cytosol
- presynaptic membrane
- nucleoplasm
- synaptosomes
- synapse
- recycling endosomes
- perikaryon
- dendrites
- postsynaptic density
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gripap1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- dendrite
- intracellular membrane-bounded organelle
- blood microparticle
- cytosol
- recycling endosome membrane
- neuronal cell body
- axon
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ionotropic glutamate receptor binding
- identical protein binding
- protein binding
- guanyl-nucleotide exchange factor activity