PDIA4 Gene Summary [Human]
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. This protein, when bound to cyclophilin B, enhances the rate of immunoglobulin G intermolecular disulfide bonding and antibody assembly. [provided by RefSeq, Dec 2016]
Details
| Type | Protein Coding |
| Official Symbol | PDIA4 |
| Official Name | protein disulfide isomerase family A member 4 [Source:HGNC Symbol;Acc:HGNC:30167] |
| Ensembl ID | ENSG00000155660 |
| Bio databases IDs | |
| Aliases | protein disulfide isomerase family A member 4 |
| Synonyms | AI987846, Cab2, Cabp2, Cai, Endoplasmic Reticulum Stress Protein 72, ERP70, ERP72, protein disulfide isomerase associated 4, protein disulfide isomerase family A member 4, protein disulfide isomerase family A, member 4, U48620 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDIA4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein disulfide-isomerase
- thioredoxin-like domain
- protein disulfide oxidoreductase
- Thioredoxin-like
- enzyme
- protein binding
- thioredoxin
- protein disulfide isomerase, eukaryotic
- integrin binding
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- a-type thioredoxin-like domain
- active site
- protein disulfide-isomerase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ovarian cancer
- HER2 negative hormone receptor negative breast cancer
- prostate cancer
- cold thyroid nodule
- hypothyroidism
role in cell
- expression in
- migration
- apoptosis
- activation in
- degradation in
- invasion by
- proliferation
- phosphorylation in
- accumulation
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- pH resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- cell surface
- Extracellular Space
- Nucleus
- Endoplasmic Reticulum
- lipid droplets
- cytosol
- endoplasmic reticulum lumen
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDIA4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chaperone-mediated protein folding
- protein folding
- protein secretion
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- melanosome
- endoplasmic reticulum
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein disulfide oxidoreductase activity
- RNA binding
- protein binding
- protein disulfide isomerase activity