ST6GALNAC2 Gene Summary [Human]
ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | ST6GALNAC2 |
| Official Name | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:10867] |
| Ensembl ID | ENSG00000070731 |
| Bio databases IDs | |
| Aliases | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 |
| Synonyms | II, SAITL1, Sialyltransferase 7B, SIAT7, SIAT7B, SIATL1, ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2, ST6GalNAc, ST6GalNAcII, ST6GalNAII, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2, ST6 N-acetylgalactosaminide α-2,6-sialyltransferase 2, ST6 (α-N-acetyl-neuraminyl-2,3-β-galactosyl-1,3)-N-acetylgalactosaminide α-2,6-sialyltransferase 2, STHM |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ST6GALNAC2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 29 (sialyltransferase)
- glycosyltransferase family 29
- sialyltransferase
- alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
- enzyme
- (alpha-N-acetylneuraminyl-2,3-alpha-galactosyl-1,3)-N-acetyl-galactosaminide alpha-2,6-sialyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ST6GALNAC2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral protein processing
- protein O-linked glycosylation
- protein glycosylation
- O-glycan processing
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
- sialyltransferase activity