EXD2 Gene Summary [Human]
Enables 3'-5' exonuclease activity; metal ion binding activity; and protein homodimerization activity. Involved in nucleic acid metabolic process. Located in intermediate filament cytoskeleton; mitochondrial outer membrane; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | EXD2 |
| Official Name | exonuclease 3'-5' domain containing 2 [Source:HGNC Symbol;Acc:HGNC:20217] |
| Ensembl ID | ENSG00000081177 |
| Bio databases IDs | |
| Aliases | exonuclease 3'-5' domain containing 2 |
| Synonyms | 4930539P14Rik, C14orf114, EXDL2, exonuclease 3'-5' domain containing 2, RGD1311087 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EXD2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'-5' exoribonuclease
- 3'-5' exonuclease
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- protein homodimerization
- enzyme
- protein binding
- manganese ion binding
- single-stranded DNA specific 3'-5' exodeoxyribonuclease
- magnesium ion binding
- 3'-5' exodeoxyribonuclease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intermediate filament cytoskeleton
- Mitochondria
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EXD2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleic acid metabolic process
- DNA double-strand break processing
- double-strand break repair via homologous recombination
- replication fork processing
- double-strand break repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- intermediate filament cytoskeleton
- mitochondrial matrix
- cytoplasm
- mitochondrion
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- nucleic acid binding
- 3'-5' exonuclease activity
- 3'-5'-exoribonuclease activity
- protein homodimerization activity
- protein binding
- 3'-5'-exodeoxyribonuclease activity
- manganese ion binding
- single-stranded DNA specific 3'-5' exodeoxyribonuclease activity