PPP1R15A Gene Summary [Human]
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PPP1R15A |
| Official Name | protein phosphatase 1 regulatory subunit 15A [Source:HGNC Symbol;Acc:HGNC:14375] |
| Ensembl ID | ENSG00000087074 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1 regulatory subunit 15A, growth arrest and DNA-damage-inducible 34 |
| Synonyms | 9630030H21, GADD34, MYD116, Myeloid Differentiation, Myeloid differentiation (MyD) primary response gene 116, Peg-3, PP1 REGULATORY subunit, protein phosphatase 1 regulatory subunit 15A, protein phosphatase 1, regulatory subunit 15A, RGD1624209 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP1R15A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PEST domain
- protein phosphatase 1 binding
- protein kinase binding
- protein phosphatase binding
- protein phosphatase regulator
- PP1 binding domain
- phosphatase activator
- protein binding
Pathways
Biological processes and signaling networks where the PPP1R15A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hypersplenism
- ischemia
- myocarditis
- leptocytosis
- anisopoikilocytosis
- mumps
- cancer cachexia
- cervical cancer
- acanthocytosis
role in cell
- expression in
- contact growth inhibition
- proliferation
- apoptosis
- phosphorylation in
- production in
- growth
- quantity
- binding in
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP1R15A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of phosphoprotein phosphatase activity
- positive regulation of phosphoprotein phosphatase activity
- apoptotic process
- positive regulation of translational initiation in response to stress
- protein localization in endoplasmic reticulum
- negative regulation of protein dephosphorylation
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- regulation of cell cycle
- response to DNA damage stimulus
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- protein phosphatase type 1 complex
- cytoplasm
- membrane
- mitochondrion
- cytosol
- Golgi apparatus
- endoplasmic reticulum
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- protein phosphatase activator activity
- protein phosphatase 1 binding
- protein phosphatase regulator activity