KIF3A Gene Summary [Human]
Enables protein phosphatase binding activity; small GTPase binding activity; and spectrin binding activity. Involved in protein localization to cell junction and protein transport. Located in centriole and centrosome. Part of kinesin II complex. Colocalizes with spindle microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | KIF3A |
| Official Name | kinesin family member 3A [Source:HGNC Symbol;Acc:HGNC:6319] |
| Ensembl ID | ENSG00000131437 |
| Bio databases IDs | |
| Aliases | kinesin family member 3A, kinesin family protein 3A |
| Synonyms | AF180004, AF180009, AW124694, FLA10, Kif3, Kifl, kinesin family member 3A, KLP-20, Kns3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KIF3A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Myosin and Kinesin motor domain
- protein phosphatase binding
- spectrin binding
- enzyme binding
- enzyme
- protein binding
- kinesin binding
- Kinesin motor, catalytic domain
- microtubule binding
- Tropomyosin
- Centromere protein H (CENP-H)
- binding protein
- Kinesin motor domain
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- plus-end-directed kinesin ATPase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- asthma
- allergic asthma
- tumorigenesis
- hypoplasia
- azoxymethane/dextran sodium sulfate induced colorectal cancer
- atopic dermatitis
- edema
- pericardial effusion
- cancer
role in cell
- accumulation
- apoptosis
- expression in
- proliferation
- formation
- production in
- quantity
- loss
- degeneration
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble membrane fraction
- soluble fraction
- detergent-insoluble fractions
- motile cilia
- glutaminergic synapse
- microtubule cytoskeleton
- ciliary tip
- cilia
- postsynaptic region
- basal bodies
- vesicles
- centrosome
- centriole
- microtubules
- axonemes
- cytosol
- connecting cilia
- spindle fibers
- neurites
- nerve ending
- photoreceptor inner segments
- apical vesicles
- cellular protrusions
- perikaryon
- dendritic knobs
- ribbon synapse
- axonal shafts
- rod outer segments
- rod inner segments
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KIF3A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- plus-end-directed vesicle transport along microtubule
- anterograde axon cargo transport
- cilium morphogenesis
- protein transport
- centriole-centriole cohesion
- microtubule anchoring at centrosome
- organelle organization
Cellular Component
Where in the cell the gene product is active
- spindle microtubule
- centrosome
- microtubule cytoskeleton
- extracellular vesicular exosome
- centriole
- cilium
- kinesin II complex
- cytosol
- kinesin complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- microtubule motor activity
- protein phosphatase binding
- protein binding
- spectrin binding
- small GTPase binding
- plus-end-directed microtubule motor activity
- microtubule binding