GADD45A Gene Summary [Human]
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | GADD45A |
| Official Name | growth arrest and DNA damage inducible alpha [Source:HGNC Symbol;Acc:HGNC:4095] |
| Ensembl ID | ENSG00000116717 |
| Bio databases IDs | |
| Aliases | growth arrest and DNA damage inducible alpha |
| Synonyms | DDIT1, Gadd, GADD45, GADD45 alpha, GADD45α, growth arrest and DNA-damage-inducible 45 alpha, growth arrest and DNA-damage-inducible 45 α, Growth arrest and DNA-damage-inducible 45, α, growth arrest and DNA damage inducible alpha, growth arrest and DNA-damage-inducible, alpha, growth arrest and DNA damage inducible α, growth arrest and DNA-damage-inducible, α |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GADD45A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dimerization domain
- kinase binding
- Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
- protein homodimerization
- chromatin binding
- protein binding
- protein heterodimerization
- Cdc2 binding domain
Pathways
Biological processes and signaling networks where the GADD45A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- endothelial dysfunction
- cancer
- hyperplasia
- autoimmune disease
- epileptic seizure
- proteinuria
- septic shock
- glioma
- glioma formation
role in cell
- expression in
- apoptosis
- activation in
- phosphorylation in
- activation
- proliferation
- survival
- differentiation
- migration
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nuclear foci
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GADD45A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of peptidyl-serine phosphorylation of STAT protein
- DNA repair
- negative regulation of angiogenesis
- negative regulation of blood vessel endothelial cell migration
- centrosome cycle
- signal transduction in response to DNA damage
- regulation of cyclin-dependent protein kinase activity
- positive regulation of p38MAPK cascade
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to mechanical stimulus
- positive regulation of JNK cascade
- positive regulation of apoptotic process
- apoptotic process
- cellular response to ionizing radiation
- regulation of cell cycle
- negative regulation of protein serine/threonine kinase activity
- positive regulation of reactive oxygen species metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- kinase binding