LYN Gene Summary [Human]
This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Details
| Type | Protein Coding |
| Official Symbol | LYN |
| Official Name | LYN proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6735] |
| Ensembl ID | ENSG00000254087 |
| Bio databases IDs | |
| Aliases | LYN proto-oncogene, Src family tyrosine kinase |
| Synonyms | Hck-2, JTK8, LOC100862590, LYN KINASE, LYN proto-oncogene, Src family tyrosine kinase, p53/56 Lyn, p53Lyn, p53/p56 Lyn, p56Lyn, SAIDV |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LYN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase
- kinase noncatalytic C-lobe domain
- N-terminal tail
- receptor activator
- phosphoprotein binding
- ephrin receptor binding
- phosphoinositide 3-kinase regulator
- protein-tyrosine kinase
- Protein kinase domain
- unique protein domain
- Sh3 domain binding motif
- myristoylation sequence
- ion channel binding
- Src homology 2 (SH2) domain
- Tyrosine kinase, catalytic domain
- SH4 domain
- ubiquitin protein ligase binding
- palmitoylation site
- sphingolipid binding
- Protein kinase (unclassified specificity)
- lipid binding
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- platelet-derived growth factor receptor binding
- enzyme binding
- non-membrane spanning protein tyrosine kinase
- protein binding
- receptor binding
- SH3-domain binding
- Src Homology 3 domain superfamily
- caveolin binding domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- gamma-tubulin binding
- kinase domain
- polybasic membrane localization signal
- binding protein
- Protein Kinases, catalytic domain
- erythropoietin receptor binding
- integrin binding
- tyrosine kinase domain
Pathways
Biological processes and signaling networks where the LYN gene in human plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Circadian Rhythm Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- CXCR4 Signaling
- Ephrin A Signaling
- Fc Epsilon RI Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- FcγRIIB Signaling in B Lymphocytes
- GM-CSF Signaling
- GP6 Signaling Pathway
- HER-2 Signaling in Breast Cancer
- IL-15 Production
- IL-7 Signaling Pathway
- Opioid Signaling Pathway
- p70S6K Signaling
- PI3K Signaling in B Lymphocytes
- Reelin Signaling in Neurons
- Role of Tissue Factor in Cancer
- Serotonin Receptor Signaling
- Sperm Motility
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- systemic lupus erythematosus
- hemolytic anemia
- psoriasis
- neoplastic cell transformation
- precursor B-cell acute lymphoblastic leukemia
- metastasis
- neoplasia
- glioma formation
- glomerulosclerosis
role in cell
- expression in
- activation in
- proliferation
- growth
- apoptosis
- phosphorylation in
- cell death
- cell viability
- autophagy by
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble membrane fraction
- microsomal fraction
- plasma membrane fraction
- raft fractions
- detergent-insoluble fractions
- membrane fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- endocytic vesicle membrane
- intracellular membrane-bounded organelle
- organelle
- cell periphery
- perinuclear region
- filamentous network
- actin cytoskeleton
- membrane skeleton
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- cytoplasmic face of plasma membrane
- caveolae
- mitochondrial membrane
- mitochondrial inner membrane
- lysosome membrane
- growth cone
- synaptosomes
- membrane rafts
- filopodia
- exosomes
- cell-cell adherens junctions
- detergent-soluble fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LYN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- C-X-C chemokine receptor CXCR4 signaling pathway
- protein autophosphorylation
- regulation of platelet aggregation
- response to axon injury
- positive regulation of tyrosine phosphorylation of STAT protein
- response to toxin
- hemopoietic progenitor cell differentiation
- positive regulation of Fc receptor mediated stimulatory signaling pathway
- negative regulation of myeloid leukocyte differentiation
- regulation of mast cell degranulation
- regulation of erythrocyte differentiation
- tolerance induction to self antigen
- fatty acid transport
- eosinophil differentiation
- positive regulation of neuron projection development
- positive regulation of oligodendrocyte progenitor proliferation
- JAK-STAT cascade involved in growth hormone signaling pathway
- regulation of monocyte chemotaxis
- negative regulation of toll-like receptor 4 signaling pathway
- toll-like receptor 4 signaling pathway
- adaptive immune response
- response to organic cyclic compound
- response to hormone stimulus
- response to DNA damage stimulus
- DNA damage checkpoint
- erythrocyte differentiation
- immune response-regulating cell surface receptor signaling pathway
- ephrin receptor signaling pathway
- lipopolysaccharide-mediated signaling pathway
- regulation of mast cell activation
- negative regulation of toll-like receptor 2 signaling pathway
- positive regulation of cell migration
- oligodendrocyte development
- negative regulation of MAP kinase activity
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- response to amino acid stimulus
- Fc-epsilon receptor signaling pathway
- Fc-gamma receptor signaling pathway involved in phagocytosis
- response to xenobiotic stimulus
- protein phosphorylation
- stimulatory C-type lectin receptor signaling pathway
- Fc receptor mediated inhibitory signaling pathway
- platelet degranulation
- cellular response to heat
- response to insulin stimulus
- negative regulation of B cell proliferation
- dendritic cell differentiation
- negative regulation of immune response
- regulation of B cell receptor signaling pathway
- negative regulation of mast cell proliferation
- positive regulation of mast cell proliferation
- B cell receptor signaling pathway
- positive regulation of dendritic cell apoptotic process
- T cell costimulation
- interleukin-5-mediated signaling pathway
- neuron projection development
- signal transduction
- positive regulation of glial cell proliferation
- response to carbohydrate stimulus
- transmembrane receptor protein tyrosine kinase signaling pathway
- response to sterol depletion
- positive regulation of MAPK cascade
- Fc receptor mediated stimulatory signaling pathway
- B cell homeostasis
- histamine secretion by mast cell
- negative regulation of inflammatory response to antigenic stimulus
- regulation of release of sequestered calcium ion into cytosol
- regulation of ERK1 and ERK2 cascade
- regulation of cell adhesion mediated by integrin
- cellular response to retinoic acid
- regulation of protein phosphorylation
- negative regulation of protein phosphorylation
- negative regulation of ERK1 and ERK2 cascade
- innate immune response
- regulation of B cell apoptotic process
- positive regulation of protein phosphorylation
- leukocyte migration
- regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- mitochondrial crista
- Golgi apparatus
- plasma membrane
- lysosomal membrane
- internal side of plasma membrane
- nucleus
- adherens junction
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- membrane raft
- alpha2-beta1 integrin complex
- cytosol
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- glycosphingolipid binding
- platelet-derived growth factor receptor binding
- ephrin receptor binding
- gamma-tubulin binding
- integrin binding
- receptor binding
- ion channel binding
- ATP binding
- scaffold protein binding
- protein tyrosine kinase activity
- protein binding
- ubiquitin protein ligase binding
- non-membrane spanning protein tyrosine kinase activity
- phosphoprotein binding
- SH3 domain binding
- kinase activity