SH2D3C Gene Summary [Human]
This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Details
| Type | Protein Coding |
| Official Symbol | SH2D3C |
| Official Name | SH2 domain containing 3C [Source:HGNC Symbol;Acc:HGNC:16884] |
| Ensembl ID | ENSG00000095370 |
| Bio databases IDs | |
| Aliases | SH2 domain containing 3C |
| Synonyms | CHAT, Chat H Sh2-containing Protein 3, NSP3, PRO34088, SH2 domain containing 3C, SHEP1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SH2D3C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Src homology 2 (SH2) domain
- Cas/HEF1 association domain
- protein binding
- transmembrane receptor protein tyrosine kinase adaptor protein
- guanine nucleotide exchange factor domain
Pathways
Biological processes and signaling networks where the SH2D3C gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- small cell lung cancer
- non-small cell lung cancer
- hypoplasia
- eating disorder
role in cell
- growth
- phosphorylation in
- proliferation
- abnormal morphology
- quantity
- extension
- migration
- production in
- penetration
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SH2D3C gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
- JNK cascade
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytosol
- ruffle membrane
- axon
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- protein binding
- guanyl-nucleotide exchange factor activity