ANXA2 Gene Summary [Human]
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Annexin A2 expression has been found to correlate with resistance to treatment against various cancer forms. [provided by RefSeq, Dec 2019]
Details
| Type | Protein Coding |
| Official Symbol | ANXA2 |
| Official Name | annexin A2 [Source:HGNC Symbol;Acc:HGNC:537] |
| Ensembl ID | ENSG00000182718 |
| Bio databases IDs | |
| Aliases | annexin A2, annexin II |
| Synonyms | annexin A2, annexin II, ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, lipocortin 2, LPC2, LPC2D, P36, PAP-IV |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANXA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- protease binding
- extracellular matrix binding
- serine protease inhibitor activity
- calcium ion binding
- calcium-dependent phospholipid binding
- enzyme binding
- protein binding
- identical protein binding
- phosphorylation site
- actin filament binding
- phosphatidylinositol-4,5-bisphosphate binding
- tail domain
- Annexin
- phospholipase A2 inhibitor
Pathways
Biological processes and signaling networks where the ANXA2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- prostate cancer
- adenoma formation
- epithelial cancer
- cancer
- Parkinson disease
- bleeding
- colorectal cancer
- diethylnitrosamine-induced hepatocellular carcinoma
- diethylnitrosamine-induced liver tumorigenesis
role in cell
- apoptosis
- proliferation
- expression in
- differentiation
- binding
- growth
- activation
- adhesion
- migration
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- prostasome
- caveolae-derived endocytic vesicles
- cornified envelope
- cell junction
- ruffle
- noncaveolar lipid raft
- exocytic vesicle
- extracellular vesicles
- azurophil granule lumen
- Cytoplasm
- cell surface
- Extracellular Space
- basal compartment
- perinuclear region
- cellular membrane
- cell cortex
- Nucleus
- endosomes
- vesicles
- midbody
- intercellular junctions
- cell-cell contacts
- lipid droplets
- cytosol
- microsome
- apical membrane
- basolateral membrane
- lateral plasma membrane
- lysosome membrane
- endosomal membrane
- nucleoli
- myelin sheath inner loop
- Schmidt-Lanterman incisures
- sarcolemma
- early endosomes
- late endosomes
- actin stress fibers
- anchoring junction
- extracellular matrix
- microsomal membrane
- membrane rafts
- exosomes
- cell-cell adherens junctions
- plasma
- macropinosomes
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ANXA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- mRNA transcription from RNA polymerase II promoter
- osteoclast development
- negative regulation of receptor internalization
- positive regulation of vesicle fusion
- fibrinolysis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of exocytosis
- negative regulation of low-density lipoprotein particle receptor catabolic process
- membrane raft assembly
- membrane budding
- positive regulation of receptor recycling
- angiogenesis
- positive regulation of plasminogen activation
- collagen fibril organization
- response to activity
- positive regulation of vacuole organization
- regulation of neurogenesis
- lung development
Cellular Component
Where in the cell the gene product is active
- extracellular region
- early endosome
- basement membrane
- endosome
- extracellular vesicular exosome
- sarcolemma
- cytosol
- azurophil granule lumen
- lysosomal membrane
- plasma membrane
- cell surface
- lipid particle
- late endosome membrane
- nucleus
- adherens junction
- cornified envelope
- extracellular space
- myelin sheath adaxonal region
- cytoplasm
- melanosome
- Schmidt-Lanterman incisure
- vesicle membrane
- membrane raft
- membrane
- nuclear matrix
- vesicle
- midbody
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- calcium-dependent protein binding
- protease binding
- S100 protein binding
- calcium-dependent phospholipid binding
- phosphatidylinositol-4,5-bisphosphate binding
- serine-type endopeptidase inhibitor activity
- phosphatidylserine binding
- protein binding
- RNA binding
- calcium ion binding
- cytoskeletal protein binding
- phospholipase A2 inhibitor activity