Sh2d3c Gene Summary [Rat]
Predicted to enable guanyl-nucleotide exchange factor activity and phosphotyrosine residue binding activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be located in cytosol. Orthologous to human SH2D3C (SH2 domain containing 3C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sh2d3c |
| Official Name | SH2 domain containing 3C [Source:RGD Symbol;Acc:1307287] |
| Ensembl ID | ENSRNOG00000054560 |
| Bio databases IDs | |
| Aliases | SH2 domain containing 3C |
| Synonyms | CHAT, Chat H Sh2-containing Protein 3, NSP3, PRO34088, SH2 domain containing 3C, SHEP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sh2d3c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Src homology 2 (SH2) domain
- Cas/HEF1 association domain
- protein binding
- transmembrane receptor protein tyrosine kinase adaptor protein
- guanine nucleotide exchange factor domain
Pathways
Biological processes and signaling networks where the Sh2d3c gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- small cell lung cancer
- non-small cell lung cancer
- hypoplasia
- eating disorder
role in cell
- growth
- phosphorylation in
- proliferation
- abnormal morphology
- quantity
- extension
- migration
- production in
- penetration
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sh2d3c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
- JNK cascade
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytosol
- ruffle membrane
- axon
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- protein binding
- guanyl-nucleotide exchange factor activity