TCFL5 Gene Summary [Human]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell population proliferation; and spermatogenesis. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TCFL5 |
| Official Name | transcription factor like 5 [Source:HGNC Symbol;Acc:HGNC:11646] |
| Ensembl ID | ENSG00000101190 |
| Bio databases IDs | |
| Aliases | transcription factor like 5, HPV-16 E2 binding protein 1 |
| Synonyms | AV260129, bHLHe82, CHA, E2BP-1, Figlb, RGD1305899, SOSF1, transcription factor like 5, transcription factor-like 5 (basic helix-loop-helix) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TCFL5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- nucleic acid binding
- basic Helix Loop Helix (bHLH) domain superfamily
- sequence-specific DNA binding
- transcription factor activity
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TCFL5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cell differentiation
- spermatogenesis
- cell differentiation
- regulation of transcription, DNA-dependent
- transcription from RNA polymerase II promoter
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity