TRIM25 Gene Summary [Human]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein is an RNA binding protein, functions as a ubiquitin E3 ligase and is involved in multiple cellular processes, including regulation of antiviral innate immunity. [provided by RefSeq, Sep 2021]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | TRIM25 |
| Official Name | tripartite motif containing 25 [Source:HGNC Symbol;Acc:HGNC:12932] |
| Ensembl ID | ENSG00000121060 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 25 |
| Synonyms | EFP, estrogen-responsive finger, RNF147, TRIM25 alpha, TRIM25 α, tripartite motif-containing 25, Z147, Zfp147, ZNF147 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- SPRY domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- B box/coiled coil domain
- coiled-coil domain
- enzyme
- Ring finger domain
- protein binding
- receptor binding
- associated with SPRY domains
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- Box B domain
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the TRIM25 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- head and neck neoplasia
- organismal death
- glioma
- glioma formation
- glioblastoma
- glioblastoma cancer
- idiopathic inflammatory myopathy
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- myopia
role in cell
- activation in
- proliferation
- apoptosis
- growth
- differentiation
- signaling
- ferroptosis
- invasion by
- cell cycle progression
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear body
- Nucleus
- cytoplasmic particles
- granules
- cytosol
- nucleoplasm
- nuclear bodies
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- protein K48-linked ubiquitination
- response to vitamin D
- regulation of protein localization
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- protein monoubiquitination
- ubiquitin-dependent protein catabolic process
- response to oxidative stress
- cytoplasmic pattern recognition receptor signaling pathway
- regulation of viral entry into host cell
- release of virus from host
- negative regulation of viral entry into host cell
- positive regulation of transcription, DNA-dependent
- innate immune response
- RIG-I signaling pathway
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cytoplasmic stress granule
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- RNA binding
- transcription coactivator activity
- metal ion binding
- cadherin binding
- RIG-I binding
- ligase activity