SPEF1 Gene Summary [Human]
Enables actin binding activity. Involved in filopodium assembly; lamellipodium assembly; and negative regulation of cell death. Located in several cellular components, including basolateral plasma membrane; lamellipodium; and microvillus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SPEF1 |
| Official Name | sperm flagellar 1 [Source:HGNC Symbol;Acc:HGNC:15874] |
| Ensembl ID | ENSG00000101222 |
| Bio databases IDs | |
| Aliases | sperm flagellar 1, CaLponin-homology And Microtubule-associated Protein |
| Synonyms | 4931426K16Rik, C20orf28, CLAMP, RGD1311267, SPEF1A, sperm flagellar 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPEF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CH-like domain in sperm protein
- microtubule binding
- actin binding
- calponin homology (CH) domain superfamily
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- ciliary tip
- microtubules
- axonemes
- apical membrane
- basolateral membrane
- microvilli
- filopodia
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPEF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule bundle formation
- regulation of cytoskeleton organization
- regulation of Wnt receptor signaling pathway, planar cell polarity pathway
- negative regulation of microtubule depolymerization
- lamellipodium assembly
- cilium movement
- filopodium assembly
- cell migration
Cellular Component
Where in the cell the gene product is active
- microvillus
- cytoplasm
- stress fiber
- filopodium
- basolateral plasma membrane
- axoneme
- apical plasma membrane
- lamellipodium
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- microtubule binding