METTL4 Gene Summary [Human]
Enables RNA methyltransferase activity and site-specific DNA-methyltransferase (adenine-specific) activity. Involved in nucleic acid metabolic process; regulation of RNA metabolic process; and regulation of mitochondrial DNA replication. Located in cytosol; mitochondrial matrix; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | METTL4 |
| Official Name | methyltransferase like 4 [Source:HGNC Symbol;Acc:HGNC:24726] |
| Ensembl ID | ENSG00000101574 |
| Bio databases IDs | |
| Aliases | methyltransferase like 4, methyltransferase 4, N6-adenosine |
| Synonyms | 2410198H06RIK, A730091E08RIK, HsT661, methyltransferase 4, N6-adenosine, RGD1306451 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human METTL4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MT-A70
- RNA methyltransferase
- enzyme
- site-specific DNA-methyltransferase (adenine-specific)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human METTL4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression, epigenetic
- regulation of RNA splicing
- regulation of mitochondrial DNA replication
- methylation
- mRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- cytosol
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- RNA methyltransferase activity
- site-specific DNA-methyltransferase (adenine-specific) activity