NCBP1 Gene Summary [Human]
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NCBP1 |
| Official Name | nuclear cap binding protein subunit 1 [Source:HGNC Symbol;Acc:HGNC:7658] |
| Ensembl ID | ENSG00000136937 |
| Bio databases IDs | |
| Aliases | nuclear cap binding protein subunit 1 |
| Synonyms | AU014645, AW538051, CBP80, NCBP, NCBP 80 kDa subunit, Nuclear cap binding protein 80 kd, nuclear cap binding protein subunit 1, Sto1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NCBP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA 7-methylguanosine cap binding
- RNA cap binding
- MIF4G domain
- MIF4G like
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- diffuse large B-cell lymphoma
role in cell
- proliferation
- expression in
- growth
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Mitochondria
- cytosol
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NCBP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- regulation of translational initiation
- nuclear mRNA splicing, via spliceosome
- RNA catabolic process
- positive regulation of transcription elongation from RNA polymerase II promoter
- positive regulation of cell growth
- mRNA metabolic process
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- positive regulation of nuclear mRNA splicing, via spliceosome
- alternative nuclear mRNA splicing, via spliceosome
- defense response to virus
- mRNA transcription from RNA polymerase II promoter
- primary miRNA processing
- posttranscriptional gene silencing by RNA
- gene silencing by miRNA
- cap-dependent translational initiation
- mRNA capping
- histone mRNA metabolic process
- spliceosomal complex assembly
- mRNA export from nucleus
- regulation of mRNA processing
- snRNA export from nucleus
- positive regulation of mRNA 3'-end processing
- mRNA 3'-end processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear cap binding complex
- RNA cap binding complex
- cytoplasm
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA 7-methylguanosine cap binding
- protein binding
- RNA binding
- RNA cap binding
- mRNA binding
- binding, bridging