LOXL2 Gene Summary [Human]
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LOXL2 |
| Official Name | lysyl oxidase like 2 [Source:HGNC Symbol;Acc:HGNC:6666] |
| Ensembl ID | ENSG00000134013 |
| Bio databases IDs | |
| Aliases | lysyl oxidase like 2 |
| Synonyms | LOR, LOR2, Lox2, lysyl oxidase-like 2, WS9-14 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LOXL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- copper ion binding
- Scavenger receptor cysteine-rich domain
- protein-lysine 6-oxidase
- calcium ion binding
- enzyme
- protein binding
- Lysyl oxidase
- carbohydrate binding
- Scavenger receptor Cys-rich
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- COVID-19
- breast cancer
- colon cancer
- androgenic alopecia
- lung adenocarcinoma
- lung adenocarcinoma formation
- metastasis
- chondrosarcoma
role in cell
- differentiation
- expression in
- migration
- formation
- formation in
- phosphorylation in
- proliferation
- cell viability
- morphology
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- extracellular vesicles
- Extracellular Space
- Endoplasmic Reticulum
- nucleoplasm
- perinuclear space
- chromatin
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LOXL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heterochromatin organization
- protein modification process
- sprouting angiogenesis
- response to copper ion
- endothelial cell migration
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of epithelial to mesenchymal transition
- response to hypoxia
- negative regulation of transcription, DNA-dependent
- peptidyl-lysine oxidation
- endothelial cell proliferation
- epithelial to mesenchymal transition
- positive regulation of chondrocyte differentiation
- collagen fibril organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- basement membrane
- membrane
- endoplasmic reticulum
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- oligosaccharide binding
- protein binding
- copper ion binding
- calcium ion binding
- protein-lysine 6-oxidase activity