ZP2 Gene Summary [Human]
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Details
| Type | Protein Coding |
| Official Symbol | ZP2 |
| Official Name | zona pellucida glycoprotein 2 [Source:HGNC Symbol;Acc:HGNC:13188] |
| Ensembl ID | ENSG00000103310 |
| Bio databases IDs | |
| Aliases | zona pellucida glycoprotein 2, zona pellucida 2 |
| Synonyms | OOMD6, OZEMA6, zona pellucida glycoprotein 2, ZPA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zona pellucida-like domain
- Zona pellucida (ZP) domain
- enzyme binding
- extracellular matrix structural constituent
- protein binding
- identical protein binding
- coreceptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- intracellular space
- cellular membrane
- Plasma Membrane
- vesicles
- Endoplasmic Reticulum
- zona pellucida
- multivesicular bodies
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of acrosome reaction
- binding of sperm to zona pellucida
- prevention of polyspermy
Cellular Component
Where in the cell the gene product is active
- egg coat
- endoplasmic reticulum
- multivesicular body
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- identical protein binding
- protein binding
- structural constituent of egg coat
- acrosin binding