GAPDHS Gene Summary [Human]
This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GAPDHS |
| Official Name | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic [Source:HGNC Symbol;Acc:HGNC:24864] |
| Ensembl ID | ENSG00000105679 |
| Bio databases IDs | |
| Aliases | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic |
| Synonyms | GAPD2, GAPDH-2, GAPDS, glyceraldehyde-3-phosphate dehydrogenase, spermatogenic, HEL-S-278, HSD-35 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GAPDHS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- glyceraldehyde-3-phosphate dehydrogenase, type I
- GAPDH-like_N
- erythrose-4-phosphate dehydrogenase
- GAPDH_like_C
- Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
- enzyme
- protein binding
- Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
- glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- cilia
- cytosol
- acrosome
- sperm fibrous sheath
- cytoplasmic droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GAPDHS gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm motility
- glycolysis
- glucose metabolic process
- positive regulation of glycolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- NADP binding
- protein binding
- NAD binding
- glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity