TRIP4 Gene Summary [Human]
This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016]
Details
| Type | Processed Transcript |
| Official Symbol | TRIP4 |
| Official Name | thyroid hormone receptor interactor 4 [Source:HGNC Symbol;Acc:HGNC:12310] |
| Ensembl ID | ENSG00000103671 |
| Bio databases IDs | |
| Aliases | thyroid hormone receptor interactor 4, zinc finger, C2HC5-type, Activating Signal Cointegrator-1 |
| Synonyms | 4930558E03RIK, ASC-1, HsT17391, MDCDC, SMABF1, thyroid hormone receptor interactor 4, ZC2HC5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIP4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- ligand-dependent nuclear receptor interactor
- transcription co-activator
- protein kinase binding
- protease binding
- ASCH
- enzyme binding
- Putative zinc finger motif, C2HC5-type
- protein binding
- estrogen receptor binding
- histone acetyltransferase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- spinal muscular atrophy with congenital bone fractures 1
- neoplasia
- Alzheimer disease
- centronuclear myopathy
- Davignon-Chauveau type congenital muscular dystrophy
- sporadic parathyroid adenoma
- parathyroid adenoma
- pericarditis
regulated by
- beta-estradiol
- N,N,N',N'-tetrakis(2-pyridyl-methyl)ethylenediamine
- L-triiodothyronine
- alitretinoin
- ESR1
role in cell
- activation in
- differentiation
- disassembly
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- nucleoplasm
- nuclear bodies
- neuromuscular junctions
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIP4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of myoblast differentiation
- positive regulation of transcription, DNA-dependent
- rescue of stalled ribosome
- ribosome disassembly
- regulation of transcription, DNA-dependent
- intracellular estrogen receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- nuclear body
- cytoplasm
- cytosol
- neuromuscular junction
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- zinc ion binding
- ligand-dependent nuclear receptor binding
- histone acetyltransferase binding
- protein binding
- transcription coactivator activity
- protease binding
- estrogen receptor binding
- small conjugating protein ligase binding