Trip4 Gene Summary [Rat]
Predicted to enable enzyme binding activity; nuclear estrogen receptor binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including estrogen receptor signaling pathway; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to be located in several cellular components, including centrosome; neuromuscular junction; and nuclear body. Predicted to be part of RQC-trigger complex. Predicted to be active in nucleus. Orthologous to human TRIP4 (thyroid hormone receptor interactor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trip4 |
| Official Name | thyroid hormone receptor interactor 4 [Source:RGD Symbol;Acc:1306838] |
| Ensembl ID | ENSRNOG00000016121 |
| Bio databases IDs | |
| Aliases | thyroid hormone receptor interactor 4 |
| Synonyms | 4930558E03RIK, ASC-1, HsT17391, MDCDC, SMABF1, thyroid hormone receptor interactor 4, ZC2HC5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Trip4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- ligand-dependent nuclear receptor interactor
- transcription co-activator
- protein kinase binding
- protease binding
- ASCH
- enzyme binding
- Putative zinc finger motif, C2HC5-type
- protein binding
- estrogen receptor binding
- histone acetyltransferase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- spinal muscular atrophy with congenital bone fractures 1
- neoplasia
- Alzheimer disease
- centronuclear myopathy
- Davignon-Chauveau type congenital muscular dystrophy
- sporadic parathyroid adenoma
- parathyroid adenoma
- pericarditis
regulated by
- beta-estradiol
- N,N,N',N'-tetrakis(2-pyridyl-methyl)ethylenediamine
- L-triiodothyronine
- alitretinoin
- ESR1
role in cell
- activation in
- differentiation
- disassembly
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- nucleoplasm
- nuclear bodies
- neuromuscular junctions
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Trip4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of myoblast differentiation
- positive regulation of transcription, DNA-dependent
- rescue of stalled ribosome
- ribosome disassembly
- regulation of transcription, DNA-dependent
- intracellular estrogen receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- nuclear body
- cytoplasm
- cytosol
- neuromuscular junction
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- zinc ion binding
- ligand-dependent nuclear receptor binding
- histone acetyltransferase binding
- protein binding
- transcription coactivator activity
- protease binding
- estrogen receptor binding
- small conjugating protein ligase binding