ZMYND8 Gene Summary [Human]
The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ZMYND8 |
| Official Name | zinc finger MYND-type containing 8 [Source:HGNC Symbol;Acc:HGNC:9397] |
| Ensembl ID | ENSG00000101040 |
| Bio databases IDs | |
| Aliases | zinc finger MYND-type containing 8, RACK like clone 7 |
| Synonyms | 1110013E22Rik, 2010005I16Rik, 3632413B07RIK, AL024039, PKC binding protein 1, PRKCBP1, PRO2893, protein KINASE C binding protein 1, RACK7, spikar, zinc finger MYND-type containing 8, zinc finger, MYND-type containing 8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZMYND8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- PHD zinc finger
- transcription regulator
- MYND finger
- transcription co-repressor
- protein binding activity, bridging
- PWWP domain
- transcription factor binding
- PWWP (Pro-Trp-Trp-Pro) domain
- protein domain specific binding
- protein binding
- Bromodomain
- Protein kinase C-binding protein 1
- zinc ion binding
- PHD finger superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- migraines
- Huntington disease
- major depression
- neuroticism
- neurodevelopmental disorder
- renal clear cell adenocarcinoma
- renal clear cell cancer
- insomnia
- depressive disorder
- psoriatic arthritis
regulated by
- lipopolysaccharide
- curcumin
- STK3
- glutamine
- trichostatin A
- topotecan
- metronidazole
- kanamycin A
- vancomycin
- colistin
role in cell
- expression in
- cell viability
- growth
- migration
- assembly
- phagocytosis
- josamycin sensitivity
- missegregation
- development
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- Cytoplasm
- nucleoplasm
- nucleoli
- dendritic spines
- chromatin
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZMYND8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription elongation from RNA polymerase II promoter
- protein localization to chromatin
- nervous system development
- positive regulation of filopodium assembly
- double-strand break repair via homologous recombination
- positive regulation of dendritic spine development
- chromatin organization
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- dendritic shaft
- dendritic spine
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- zinc ion binding
- protein binding
- transcription corepressor activity
- methylated histone residue binding
- histone acetyl-lysine binding