CLASP2 Gene Summary [Human]
Enables cytoskeletal protein binding activity; dystroglycan binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including microtubule cytoskeleton organization; positive regulation of extracellular matrix organization; and regulation of supramolecular fiber organization. Located in several cellular components, including basal cortex; cortical microtubule plus-end; and ruffle membrane. Colocalizes with focal adhesion; kinetochore; and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | CLASP2 |
| Official Name | cytoplasmic linker associated protein 2 [Source:HGNC Symbol;Acc:HGNC:17078] |
| Ensembl ID | ENSG00000163539 |
| Bio databases IDs | |
| Aliases | cytoplasmic linker associated protein 2 |
| Synonyms | 1500004F14Rik, 8030404L10RIK, Clap2, Clasp, CLASP2beta, Clasp2gamma, CLIP associating protein 2, cytoplasmic linker associated protein 2, mKIAA0627 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLASP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- microtubule binding
- N2 domain
- HEAT repeat
- TOG-like domain
- protein kinase binding
- Eb1 binding domain
- microtubule plus-end binding
- arginine-serine-rich domain
- protein binding
- cortex-binding domain
- CLASP N terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Hutchinson-Gilford progeria syndrome
role in cell
- expression in
- growth
- migration
- stabilization in
- formation in
- formation
- catastrophe
- extension
- quantity
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- microtubule cytoskeleton
- axon component
- cell surface
- perinuclear region
- focal adhesions
- cell cortex
- Plasma Membrane
- Golgi Apparatus
- microtubules
- cell-cell contacts
- cytosol
- membrane ruffles
- trans Golgi network
- growth cone
- cytoplasmic microtubule
- kinetochore microtubule
- plus end of microtubule
- cell membrane leading edge
- mitotic spindle
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLASP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of gastrulation
- establishment of mitotic spindle localization
- microtubule anchoring
- mitotic spindle organization
- Golgi organization
- microtubule nucleation
- establishment or maintenance of cell polarity
- negative regulation of microtubule depolymerization
- microtubule cytoskeleton organization
- positive regulation of exocytosis
- cell division
- negative regulation of focal adhesion assembly
- regulation of epithelial to mesenchymal transition
- positive regulation of extracellular matrix disassembly
- negative regulation of stress fiber assembly
- vesicle targeting
- regulation of microtubule polymerization or depolymerization
- exit from mitosis
- positive regulation of epithelial cell migration
- microtubule organizing center organization
- protein localization in plasma membrane
- regulation of microtubule-based process
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- cell leading edge
- Golgi apparatus
- cytoplasmic microtubule
- kinetochore
- plasma membrane
- microtubule
- spindle microtubule
- centrosome
- trans-Golgi network
- mitotic spindle
- microtubule organizing center
- focal adhesion
- cytoplasm
- cell cortex
- kinetochore microtubule
- membrane
- cytosol
- ruffle membrane
- basal cortex
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule plus-end binding
- dystroglycan binding
- microtubule binding