MTFMT Gene Summary [Human]
The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA. [provided by RefSeq, Jun 2011]
Details
| Type | Protein Coding |
| Official Symbol | MTFMT |
| Official Name | mitochondrial methionyl-tRNA formyltransferase [Source:HGNC Symbol;Acc:HGNC:29666] |
| Ensembl ID | ENSG00000103707 |
| Bio databases IDs | |
| Aliases | mitochondrial methionyl-tRNA formyltransferase |
| Synonyms | 2310020P08RIK, COXPD15, FMT1, MC1DN27, methionyl-tRNA transformylase, mitochondrial, mitochondrial methionyl-tRNA formyltransferase, RGD1309462 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MTFMT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methionyl-tRNA formyltransferase
- Formyl transferase, C-terminal domain
- Formyltransferase, catalytic core domain
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- combined oxidative phosphorylation deficiency 15
- hereditary disorder
- nonalcoholic fatty liver disease
- nuclear type 27 mitochondrial complex I deficiency
- Leigh syndrome
- oxidative phosphorylation disease
regulated by
- tetradecanoylphorbol acetate
- NUPR1
- GSKJ4
role in cell
- josamycin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MTFMT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- conversion of methionyl-tRNA to N-formyl-methionyl-tRNA
- translational initiation
Cellular Component
Where in the cell the gene product is active
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- methionyl-tRNA formyltransferase activity