TCEAL1 Gene Summary [Human]

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
TCEAL1
Official Name
transcription elongation factor A like 1 [Source:HGNC Symbol;Acc:HGNC:11616]
Ensembl ID
ENSG00000172465
Bio databases IDs NCBI: 9338 Ensembl: ENSG00000172465
Aliases transcription elongation factor A like 1
Synonyms 0610011M09RIK, BC011290, HIJRS, NEDGFAX, P21, pp21, SIIR, transcription elongation factor A like 1, transcription elongation factor A (SII)-like 1, WEX9
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TCEAL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • transcription regulator
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • Hijazi-Reis syndrome
  • hereditary disorder
  • adult T-cell leukemia/lymphoma
  • mature T-cell neoplasia
  • T-cell non-Hodgkin disease
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human TCEAL1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of gene expression

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

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