SLIRP Gene Summary [Human]
Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLIRP |
| Official Name | SRA stem-loop interacting RNA binding protein [Source:HGNC Symbol;Acc:HGNC:20495] |
| Ensembl ID | ENSG00000119705 |
| Bio databases IDs | |
| Aliases | SRA stem-loop interacting RNA binding protein |
| Synonyms | 1810035L17Rik, C14orf156, DC50, LOC681987, PD04872, SRA stem-loop interacting RNA binding protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLIRP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- Huntington disease
- mitochondrial encephalomyopathy
role in cell
- development
- motility
- abnormal morphology
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Mitochondria
- mitochondrial matrix
- sperm tail
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLIRP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm motility
- spermatid development
- negative regulation of mitochondrial RNA catabolic process
- single fertilization
- mitochondrion organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- mitochondrial matrix
- acrosomal vesicle
- mitochondrion
- sperm flagellum
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding