SLC5A5 Gene Summary [Human]
This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | SLC5A5 |
| Official Name | solute carrier family 5 member 5 [Source:HGNC Symbol;Acc:HGNC:11040] |
| Ensembl ID | ENSG00000105641 |
| Bio databases IDs | |
| Aliases | solute carrier family 5 member 5 |
| Synonyms | NIS, solute carrier family 5 member 5, solute carrier family 5 (sodium iodide symporter), member 5, TDH1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC5A5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sodium:iodide symporter
- protein homodimerization
- protein binding
- Solute carrier families 5 and 6-like; solute binding domain
- monovalent anion:sodium symporter
- symporter
- iodide transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- thyroid dyshormonogenesis 1
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
- cold thyroid nodule
- nonalcoholic fatty liver disease
- congenital hypothyroidism
role in cell
- migration
- cell death
- invasion by
- response by
- accumulation in
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- Nucleus
- basolateral membrane
- basal membrane
- lateral plasma membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC5A5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sodium ion transport
- ion transport
- cellular response to gonadotropin stimulus
- thyroid hormone generation
- cellular response to cAMP
- iodide transport
- sodium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- sodium:iodide symporter activity
- protein binding
- protein homodimerization activity
- iodide transmembrane transporter activity
- monovalent anion:sodium symporter activity