BAG2 Gene Summary [Human]
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | BAG2 |
| Official Name | BAG cochaperone 2 [Source:HGNC Symbol;Acc:HGNC:938] |
| Ensembl ID | ENSG00000112208 |
| Bio databases IDs | |
| Aliases | BAG cochaperone 2 |
| Synonyms | 2610042A13Rik, BAG cochaperone 2, BCL2-associated athanogene 2, dJ417I1.2, LOC679102 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BAG2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- adenyl-nucleotide exchange factor
- BAG domains, present in regulator of Hsp70 proteins
- tau protein binding
- heat shock protein binding
- ion channel binding
- protein binding
- chaperone binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- lymphoma
- androgenic alopecia
- lymphomagenesis
- organismal death
- hepatocellular carcinoma
- liver cancer
role in cell
- apoptosis
- degradation in
- production in
- viability
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Extracellular Space
- Nucleus
- Mitochondria
- microtubules
- cytosol
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BAG2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein metabolic process
- positive regulation of protein processing
- negative regulation of protein ubiquitination
- protein folding
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein stabilization
- negative regulation of protein binding
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytosol
- axon
- microtubule
Molecular Function
What the gene product does at the molecular level
- heat shock protein binding
- identical protein binding
- ubiquitin protein ligase binding
- protein binding
- tau protein binding
- chaperone binding
- adenyl-nucleotide exchange factor activity
- ion channel binding