Slc5a5 Gene Summary [Rat]
Enables sodium:iodide symporter activity. Involved in iodide transmembrane transport and sodium ion transport. Is active in plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A5 (solute carrier family 5 member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc5a5 |
| Official Name | solute carrier family 5 member 5 [Source:RGD Symbol;Acc:69267] |
| Ensembl ID | ENSRNOG00000018822 |
| Bio databases IDs | |
| Aliases | solute carrier family 5 member 5 |
| Synonyms | NIS, solute carrier family 5 member 5, solute carrier family 5 (sodium iodide symporter), member 5, TDH1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc5a5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sodium:iodide symporter
- protein homodimerization
- protein binding
- Solute carrier families 5 and 6-like; solute binding domain
- monovalent anion:sodium symporter
- symporter
- iodide transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- thyroid dyshormonogenesis 1
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
- cold thyroid nodule
- nonalcoholic fatty liver disease
- congenital hypothyroidism
role in cell
- migration
- cell death
- invasion by
- response by
- accumulation in
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- Nucleus
- basolateral membrane
- basal membrane
- lateral plasma membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc5a5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sodium ion transport
- ion transport
- cellular response to gonadotropin stimulus
- thyroid hormone generation
- cellular response to cAMP
- iodide transport
- sodium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- sodium:iodide symporter activity
- protein binding
- protein homodimerization activity
- iodide transmembrane transporter activity
- monovalent anion:sodium symporter activity