RNF167 Gene Summary [Human]
RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | RNF167 |
| Official Name | ring finger protein 167 [Source:HGNC Symbol;Acc:HGNC:24544] |
| Ensembl ID | ENSG00000108523 |
| Bio databases IDs | |
| Aliases | ring finger protein 167 |
| Synonyms | 0610010G05Rik, 5730408C10Rik, LP2254, RGD1305972, RING105, ring finger protein 167 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF167 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- PA domain
- RING-type zinc-finger
- PA
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- PHD finger superfamily
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endosomes
- lysosome
- cytosol
- lysosome membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF167 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome localization
- organelle localization
- protein K29-linked ubiquitination
- protein polyubiquitination
- negative regulation of cell cycle
- protein K63-linked ubiquitination
- regulation of synaptic transmission, glutamatergic
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- endosome
- cytoplasm
- endolysosome membrane
- cytosol
- plasma membrane
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding