RNF115 Gene Summary [Human]
Enables ubiquitin-protein transferase activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway; protein autoubiquitination; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RNF115 |
| Official Name | ring finger protein 115 [Source:HGNC Symbol;Acc:HGNC:18154] |
| Ensembl ID | ENSG00000265491 |
| Bio databases IDs | |
| Aliases | ring finger protein 115 |
| Synonyms | 2610028E05Rik, BCA2, LOC101060478, RABRING7, ring finger protein 115, Tristetraprolin, ZFP364, ZNF364 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF115 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING-type zinc-finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- enzyme
- Ring finger domain
- protein binding
- zinc-ribbon
- RING-like zinc finger
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- trigonocephaly
- metabolic syndrome X
- Moyamoya disease
- breast carcinoma
- gout
- intellectual disability and developmental delay
- epilepsy
- postmenopausal osteoporosis
role in cell
- aggregation
- maturation
- maturation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF115 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- negative regulation of toll-like receptor signaling pathway
- protein K63-linked ubiquitination
- negative regulation of epidermal growth factor receptor signaling pathway
- protein ubiquitination
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- endoplasmic reticulum
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding