MS4A4A Gene Summary [Human]
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features, similar intron/exon splice boundaries, and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | MS4A4A |
| Official Name | membrane spanning 4-domains A4A [Source:HGNC Symbol;Acc:HGNC:13371] |
| Ensembl ID | ENSG00000110079 |
| Bio databases IDs | |
| Aliases | membrane spanning 4-domains A4A |
| Synonyms | 4SPAN1, CD20-L1, EG666907, HDCME31P, LOC624461, membrane spanning 4-domains A4A, membrane-spanning 4-domains, subfamily A, member 4A, MS4A4, MS4A7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MS4A4A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- CD20-like family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- nonobstructive azoospermia
- Alzheimer disease
- late-onset Alzheimer disease
- flu
- febrile seizure
- dermatomyositis
- hypertension
- ischemic stroke
- sepsis
role in cell
- phosphorylation in
- proliferation
- signaling in
- migration
- endocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Plasma Membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- early endosomes
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MS4A4A gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding