ECPAS Gene Summary [Human]
Enables proteasome binding activity. Involved in ubiquitin-dependent ERAD pathway. Located in several cellular components, including centrosome; cytoplasmic vesicle; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ECPAS |
| Official Name | Ecm29 proteasome adaptor and scaffold [Source:HGNC Symbol;Acc:HGNC:29020] |
| Ensembl ID | ENSG00000136813 |
| Bio databases IDs | |
| Aliases | Ecm29 proteasome adaptor and scaffold, ECM29 homolog (S. cerevisiae) |
| Synonyms | BB181316, ECM29, Ecm29 proteasome adaptor and scaffold, KIAA0368, mKIAA0368, RGD1306148 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ECPAS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HEAT repeat
- binding protein
- Proteasome stabilizer
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- endosomes
- vesicles
- centrosome
- Golgi Apparatus
- Endoplasmic Reticulum
- cytoplast
- nucleoplasm
- karyoplast
- early endosomes
- late endosomes
- transport vesicles
- cytoplasmic vesicles
- endocytotic vesicle
- multivesicular bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ECPAS gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasome assembly
Cellular Component
Where in the cell the gene product is active
- late endosome
- proteasome complex
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
- multivesicular body
- nucleoplasm
- nucleus
- endocytic vesicle
- early endosome
- centrosome
- trans-Golgi network
- cytoplasm
- membrane
- cytoplasmic vesicle
- ER to Golgi transport vesicle
Molecular Function
What the gene product does at the molecular level
- protein binding
- proteasome binding
- binding, bridging