ARFGEF3 Gene Summary [Human]
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be located in transport vesicle membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ARFGEF3 |
| Official Name | ARFGEF family member 3 [Source:HGNC Symbol;Acc:HGNC:21213] |
| Ensembl ID | ENSG00000112379 |
| Bio databases IDs | |
| Aliases | ARFGEF family member 3, protein phosphatase 1, regulatory subunit 33 |
| Synonyms | 9630004D11, A7322, ARFGEF family member 3, B930094H20Rik, BIG3, C6orf92, D10Bwg1379e, dJ171N11.1, KIAA1244, LOC103690074, mKIAA1244, PPP1R33, RGD1309903 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARFGEF3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sec7
- Sec7 domain
- dimerization and cyclophilin-binding domain of Mon2
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARFGEF3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of ARF protein signal transduction
Cellular Component
Where in the cell the gene product is active
- transport vesicle membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- guanyl-nucleotide exchange factor activity